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INFRAFRONTIER––providing mutant mouse resources as research tools for the international scientific community

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    0440979 - ÚMG 2015 RIV GB eng J - Článek v odborném periodiku
    Sedláček, Radislav … celkem 43 autorů
    INFRAFRONTIER––providing mutant mouse resources as research tools for the international scientific community.
    Nucleic Acids Research. Roč. 43, D1171-5 (2014). ISSN 0305-1048. E-ISSN 1362-4962
    Institucionální podpora: RVO:68378050
    Klíčová slova: phenotyping * mutant mouse * INFRAFRONTIER
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 9.112, rok: 2014

    The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.
    Trvalý link: http://hdl.handle.net/11104/0244061

     
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