Počet záznamů: 1  

Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP

  1. 1.
    0438420 - FGU-C 2015 RIV PL eng J - Článek v odborném periodiku
    Zavala-Tecuapetla, Cecília - Kubová, Hana - Otáhal, Jakub - Tsenov, Grygoriy - Mareš, Pavel
    Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.
    Pharmacological Reports. Roč. 66, č. 5 (2014), s. 927-930. ISSN 1734-1140
    Grant CEP: GA ČR(CZ) GA305/09/0846; GA ČR(CZ) GBP304/12/G069
    Institucionální podpora: RVO:67985823
    Klíčová slova: epileptic afterdischarge * hippocampus * rat * ontogeny * metabotropic glutamate receptor 5
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 1.928, rok: 2014

    Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies
    Trvalý link: http://hdl.handle.net/11104/0241846