0437821 - FGÚ 2015 RIV US eng J - Článek v odborném periodiku
Svobodová, Michaela - Andreadou, I. - Skaltsounis, A.-L. - Kopecký, Jan - Flachs, Pavel
Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma.
Genes and Nutrition. Roč. 9, č. 1 (2014), s. 376. ISSN 1555-8932. E-ISSN 1865-3499
Grant CEP: GA ČR(CZ) GAP301/11/0226
Institucionální podpora: RVO:67985823
Klíčová slova: oleuropein * adipogenesis * PPARγ * olive oil and leaf extracts * catalase
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 2.794, rok: 2014 ; AIS: 0.819, rok: 2014
DOI: https://doi.org/10.1007/s12263-013-0376-0

Oleuropein, the major phenolic compound found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Herein, we characterized molecular mechanisms underlying the anti-adipogenic effects of oleuropein on 3T3-L1 cells and adipocytes derived from stromal-vascular fraction of dorsolumbar and gonadal fat dissected from mice. Our data suggest that oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity
Trvalý link: http://hdl.handle.net/11104/0241353