Počet záznamů: 1  

Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair

  1. 1. 0435646 - UEM-P 2016 RIV US eng J - Článek v odborném periodiku
    Romanyuk, Nataliya - Amemori, Takashi - Turnovcová, Karolína - Procházka, Pavel - Onteniente, B. - Syková, Eva - Jendelová, Pavla
    Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair.
    Cell Transplantation. Roč. 24, č. 9 (2015), s. 1781-1797. ISSN 0963-6897
    Grant CEP: GA MŠk LH12024; GA ČR(CZ) GA13-00939S; GA ČR(CZ) GBP304/12/G069; GA MŠk(CZ) ED1.1.00/02.0109; GA MŠk(CZ) LO1309
    Institucionální podpora: RVO:68378041
    Klíčová slova: human induced pluripotent stem cells * neural precursors * spinal cord injury
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.427, rok: 2015

    Neural precursors differentiated from induced pluripotent stem cells were grafted into rat spinal cord injury. They survived well and slowly mature into different neuronal phenotypes (GABAergic, serotonergic and motoneurons). In addition, they produced growth factors, stimulating neuronal sprouting. As a result, animals with spinal cord injury significantly improved their motor function. Rats were able to support their body weight and perform stepping, so they scored well in tests requiring movement coordination, such as beam walking or rotarod.
    Trvalý link: http://hdl.handle.net/11104/0252351