0435169 - BFÚ 2015 RIV GB eng J - Článek v odborném periodiku
Hofmanová, Jiřina - Straková, Nicol - Vaculová, Alena - Tylichová, Zuzana - Šafaříková, Barbora - Skender, Belma - Kozubík, Alois
Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer.
Mediators of Inflammation. Roč. 2014, April (2014). ISSN 0962-9351. E-ISSN 1466-1861
Institucionální podpora: RVO:68081707
Klíčová slova: NF-KAPPA-B * TRAIL-INDUCED APOPTOSIS * RECEPTOR-MEDIATED APOPTOSIS
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.236, rok: 2014 ; AIS: 0.913, rok: 2014
DOI: https://doi.org/10.1155/2014/848632

Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds. Malfunction of this system may result in chronic inflammation and cancer. Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities. Both compounds were shown to modulate the production and activities of TNF family cytokines. Cytokines from the TNF family (TNF-alpha,TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development. The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NF kappa B activity. This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development.
Trvalý link: http://hdl.handle.net/11104/0239094