Počet záznamů: 1  

Assessment and Reconstruction of Novel HSP90 Genes: Duplications, Gains and Losses in Fungal and Animal Lineages

  1. 1.
    0434710 - ÚMG 2015 RIV US eng J - Článek v odborném periodiku
    Pantzartzi, Chrysoula - Drosopoulou, E. - Scouras, Z.
    Assessment and Reconstruction of Novel HSP90 Genes: Duplications, Gains and Losses in Fungal and Animal Lineages.
    PLoS ONE. Roč. 8, č. 9 (2013), s. 1-11. ISSN 1932-6203. E-ISSN 1932-6203
    Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109
    Institucionální podpora: RVO:68378050
    Klíčová slova: Hsp90s * Fungi * duplication events
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.534, rok: 2013

    Hsp90s, members of the Heat Shock Protein class, protect the structure and function of proteins and play a significant task in cellular homeostasis and signal transduction. In order to determine the number of hsp90 gene copies and encoded proteins in fungal and animal lineages and through that key duplication events that this family has undergone, we collected and evaluated Hsp90 protein sequences and corresponding Expressed Sequence Tags and analyzed available genomes from various taxa. We provide evidence for duplication events affecting either single species or wider taxonomic groups. With regard to Fungi, duplicated genes have been detected in several lineages. In invertebrates, we demonstrate key duplication events in certain clades of Arthropoda and Mollusca, and a possible gene loss event in a hymenopteran family. Finally, we infer that the duplication event responsible for the two (a and b) isoforms in vertebrates occurred probably shortly after the split of Hyperoartia and Gnathostomata.
    Trvalý link: http://hdl.handle.net/11104/0241982

     
     
Počet záznamů: 1  

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