Počet záznamů: 1  

Age and activation determines the anticonvulsant effect of ifenprodil in rats

  1. 1. 0434262 - FGU-C 2015 RIV DE eng J - Článek v odborném periodiku
    Mareš, Pavel
    Age and activation determines the anticonvulsant effect of ifenprodil in rats.
    Naunyn-Schmiedeberg's Archives of Pharmacology. Roč. 387, č. 8 (2014), s. 753-761. ISSN 0028-1298
    Grant CEP: GA ČR(CZ) GBP304/12/G069
    Institucionální podpora: RVO:67985823
    Klíčová slova: NMDA receptors * NR2B subunit * anticonvulsant action * ontogeny * rat
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.471, rok: 2014

    Ifenprodil is an antagonist of MDA receptors containing NR2B subunit. This subunit is dominant at early stages of brain development and therefore the anticonvulsant effect of this drug is marked in very young rats
    Trvalý link: http://hdl.handle.net/11104/0238354