0433022 - MBÚ 2015 RIV US eng J - Článek v odborném periodiku
Šírová, Milada - van Vlierberghe, S. - Matyášová, V. - Rossmann, Pavel - Schacht, E. - Dubruel, P. - Říhová, Blanka
Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine.
Journal of Biomedical Materials Research. Part A. Roč. 102, č. 6 (2014), s. 1982-1990. ISSN 1549-3296. E-ISSN 1552-4965
Grant CEP: GA ČR GAP301/12/1254
Institucionální podpora: RVO:61388971
Klíčová slova: methacrylamide-modified gelatin * hydrogel * polyimide implant
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.369, rok: 2014

Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The results indicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels
Trvalý link: http://hdl.handle.net/11104/0237346