Počet záznamů: 1  

Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

  1. 1. 0432084 - FGU-C 2015 RIV GR eng J - Článek v odborném periodiku
    Olejár, Tomáš - Větvička, D. - Zadinová, M. - Poučková, P. - Kukal, J. - Ježek, Petr - Matěj, R.
    Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma.
    Anticancer Research. Roč. 34, č. 7 (2014), s. 3511-3515. ISSN 0250-7005
    Grant CEP: GA ČR(CZ) GAP302/10/0346
    Institucionální podpora: RVO:67985823
    Klíčová slova: PAR2 * melanoma * metastasis * murine model
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Impakt faktor: 1.826, rok: 2014

    Differences of metastatic spread of normal proteinase-activated receptor 2 (Par2+/+) melanoma B16 in Par2−/− (knock-out) animals compared with C57Bl6 mice were investigated. Excised primary tumors were in average larger in Par2−/− mice (360 mm3 vs. 221 mm3 in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2−/− mice in comparison to 6 of 9 controls. Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic spread
    Trvalý link: http://hdl.handle.net/11104/0236585