Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

0428048 - FGÚ 2015 RIV US eng J - Článek v odborném periodiku
Líšková, Silvia - Petrová, M. - Karen, Petr - Behuliak, Michal - Zicha, Josef
Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing.
BioMed Research International. Roč. 2014, č. 2014 (2014), s. 289361. ISSN 2314-6133. E-ISSN 2314-6141
Grant CEP: GA ČR(CZ) GAP304/12/0259
Institucionální podpora: RVO:67985823
Klíčová slova: calcium-dependent chloride channels * endothelium-derived contracting factor * ageing
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 1.579, rok: 2014

The activation of calcium-dependent chloride channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase calcium entry. Hypertension and ageing are associated with altered calcium handling including possible activation of calcium-dependent chloride channels. Our study was aimed to determine calcium -dependent chloride channels contribution to norepinephrine-induced contraction during hypertension and ageing. We have found that contribution of calcium -dependent chloride channels to norepinephrine-induced contraction diminished with age, hypertension development, and/or NO synthesis inhibition
Trvalý link: http://hdl.handle.net/11104/0233483