Počet záznamů: 1  

Antioxidant and regulatory role of mitochondrial uncoupling protein UCP2 in pancreatic beta-cells

  1. 1.
    0428036 - FGU-C 2015 RIV CZ eng J - Článek v odborném periodiku
    Ježek, Petr - Olejár, Tomáš - Smolková, Katarína - Ježek, Jan - Dlasková, Andrea - Plecitá-Hlavatá, Lydie - Zelenka, Jaroslav - Špaček, Tomáš - Engstová, Hana - Reguera Pajuelo, David - Jabůrek, Martin
    Antioxidant and regulatory role of mitochondrial uncoupling protein UCP2 in pancreatic beta-cells.
    Physiological Research. Roč. 63, Suppl.1 (2014), S73-S91. ISSN 0862-8408
    Grant CEP: GA ČR(CZ) GAP302/10/0346; GA ČR(CZ) GAP305/12/1247; GA ČR(CZ) GPP304/10/P204; GA MŠk(CZ) EE2.3.30.0025
    Institucionální podpora: RVO:67985823
    Klíčová slova: mitochondria * uncoupling protein UCP2 * pancreatic beta-cells * reactive oxygen species * glucose-stimulated insulin secretion
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Impakt faktor: 1.293, rok: 2014

    We review physiological roles of mitochondrial uncoupling protein UCP2 emphasising its roles in pancreatic beta-cells. We discuss the antioxidant roles of UCP2, its participation in redox regulations, and the regulation of glucose-stimulated insulin secretion. We also point out the role of phospholipase iPLA2gamma in the regulation of UCP2 antioxidant function
    Trvalý link: http://hdl.handle.net/11104/0233445