Počet záznamů: 1  

Nuclear Structures Surrounding Internal Lamin Invaginations

  1. 1.
    0427969 - BFU-R 2015 RIV US eng J - Článek v odborném periodiku
    Legartová, Soňa - Stixová, Lenka - Laur, O. - Kozubek, Stanislav - Sehnalová, Petra - Bártová, Eva
    Nuclear Structures Surrounding Internal Lamin Invaginations.
    Journal of Cellular Biochemistry. Roč. 115, č. 3 (2014), s. 476-487. ISSN 0730-2312
    Grant CEP: GA MŠk(CZ) LD11020
    Institucionální podpora: RVO:68081707
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.263, rok: 2014

    A- and C-type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C-type lamins into the nuclear interior represent channels for the transport of regulatory molecules to and from nuclear and nucleolar regions. Using fluorescent protein technology and immunofluorescence, we show that A-type lamin channels interact with several nuclear components, including fibrillarin- and UBF-positive regions of nucleoli, foci of heterochromatin protein 1 , polycomb group bodies, and genomic regions associated with DNA repair. Similar associations were observed between A/C-type lamin channels and nuclear pores, lamin-associated protein LAP2, and promyelocytic leukemia nuclear bodies. Interestingly, regions with high levels of A/C-type lamins had low levels of B-type lamins, and vice versa.
    Trvalý link: http://hdl.handle.net/11104/0233409