Počet záznamů: 1  

Electrochemical sensing of 2D condensation in amyloid peptides

  1. 1.
    0422785 - BFU-R 2014 RIV GB eng J - Článek v odborném periodiku
    Kurzatkowska, K. - Ostatná, Veronika - Hamley, I.W. - Doneux, T. - Paleček, Emil
    Electrochemical sensing of 2D condensation in amyloid peptides.
    Electrochimica acta. Roč. 106, SEP2013 (2013), s. 43-48. ISSN 0013-4686
    Grant CEP: GA ČR(CZ) GAP301/11/2055
    Institucionální podpora: RVO:68081707
    Klíčová slova: QUARTZ-CRYSTAL-MICROBALANCE * SELF-ASSEMBLED MONOLAYERS * BETA-SHEET PEPTIDES
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.086, rok: 2013

    The interfacial behavior of the model amyloid peptide octamer YYKLVFFC (peptide 1) and two other amyloid peptides YEVHHQKLVFF (peptide 2) and KKLVFFA (peptide 3) at the metal aqueous solution interface was studied by voltammetric and constant current chronopotentiometric stripping (CPS). All three peptides are adsorbed in a wide potential range and exhibit different interfacial organizations depending on the electrode potential. At the least negative potentials, chemisorption of peptide 1 occurs through the formation of a metal-sulfur bond. This bond is broken close to -0.6V. The peptide undergoes self-association at more negative potentials, leading to the formation of a "pit" characteristic of a 2D condensed film. Under the same conditions the other peptides do not produce such a pit.
    Trvalý link: http://hdl.handle.net/11104/0228926