Počet záznamů: 1
Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart
- 1.0422631 - FGÚ 2014 RIV CZ eng J - Článek v odborném periodiku
Ravingerová, T. - Čarnická, S. - Ledvényiová, V. - Barlaka, E. - Galatou, E. - Chytilová, Anna - Mandíková, Petra - Nemčeková, M. - Adameová, A. - Kolář, František - Lazou, A.
Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart.
Physiological Research. Roč. 62, Suppl.1 (2013), S151-S163. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) 7AMB12SK164
Institucionální podpora: RVO:67985823
Klíčová slova: myocardial ischemia * PPAR activation * metabolic genes * delayed preconditioning * WY-14643
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 1.487, rok: 2013
The results indicate that cardioprotection was associated with remarkably increased expression of PPAR-alpha target genes promoting FA utilization and reduced expression of glucose transporter GLUT-4. Potential non-genomic effects of PPAR-alpha-mediated cardioprotection may involve activation of prosurvival PI3K/Akt pathway and its downstream targets such as eNOS and subsequently reduced apoptosis
Trvalý link: http://hdl.handle.net/11104/0228881
Počet záznamů: 1