Počet záznamů: 1  

Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study

  1. 1. 0397116 - UEM-P 2014 RIV NL eng J - Článek v odborném periodiku
    Vymetálková, Veronika - Vannucci, Luca - Korenková, Vlasta - Procházka, Pavel - Slyšková, Jana - Vodičková, Ludmila - Rusňáková, Vendula - Bielik, Ludovít - Burocziová, Monika - Rossmann, Pavel - Vodička, Pavel
    Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study.
    Molecular Biology Reports. Roč. 40, č. 10 (2013), s. 5921-5929 ISSN 0301-4851
    Grant CEP: GA AV ČR IAA500200917; GA ČR GPP304/11/P715
    Výzkumný záměr: CEZ:AV0Z50390703; CEZ:AV0Z50520701; CEZ:AV0Z50390512
    Institucionální podpora: RVO:61388971 ; RVO:68378041 ; RVO:86652036
    Klíčová slova: colorectal cancer * rats * mRNA expression
    Kód oboru RIV: EB - Genetika a molekulární biologie; EB - Genetika a molekulární biologie (BU-J); EB - Genetika a molekulární biologie (MBU-M)
    Impakt faktor: 1.958, rok: 2013

    The aim of this pilot study was to analyze expression profile and promoter methylation status of important tumor suppressor and DNA repair genes in the early stages of experimentally induced colorectal carcinogenesis. Rats were treated with azoxymethane (AOM), dextran sodium sulphate (DSS) or with their combination, and sacrificed 1 or 4 months post-treatment period. Present data suggest that down-regulation of Apc and MMR genes are prerequisite for the development of CRC. In this study we addressed for the first time early functional alterations of tumor suppressor genes with underlying epigenetic mechanisms in experimentally induced CRC in rats.
    Trvalý link: http://hdl.handle.net/11104/0225351