0387525 - FGÚ 2013 RIV US eng J - Článek v odborném periodiku
Pietka, T. A. - Sulkin, M.S. - Kuda, Ondřej - Wang, W. - Zhou, D. - Yamada, K. A. - Yang, K. - Su, X. - Gross, R. W. - Nerbonne, J. M. - Efimov, I. R. - Abumrad, N. A.
CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING.
Journal of Biological Chemistry. Roč. 287, č. 46 (2012), s. 38901-38912. ISSN 0021-9258. E-ISSN 1083-351X
Institucionální podpora: RVO:67985823
Klíčová slova: calcium * cyclic AMP (cAMP) * heart * phospholipid * phospholipid metabolism * polyunsaturated fatty acids * CD36 deficiency * SERCA2a * sudden death
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.651, rok: 2012 ; AIS: 1.945, rok: 2012
DOI: https://doi.org/10.1074/jbc.M112.413609

Myocardial function during fasting was examined in wild-type and CD36−/− mice. CD36−/− mice have abnormalities of myocardial Ca2+, phospholipid composition, and cAMP levels and manifest electrical anomalies during fasting. Conclusion: CD36 influences myocardial adaptation by impacting Ca2+ dynamics and phospholipid metabolism. Significance: Inter-dependence of lipid metabolism and Ca2+ homeostasis can contribute to cardiac dysfunction during metabolic stress
Trvalý link: http://hdl.handle.net/11104/0220284