Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets

0387370 - ÚIACH 2013 RIV US eng J - Článek v odborném periodiku
Doulliet, Ch. - Currier, J. M. - Saunders, J. - Bodnar, W. M. - Matoušek, Tomáš - Stýblo, M.
Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets.
Toxicology and Applied Pharmacology. Roč. 267, č. 1 (2013), s. 11-15. ISSN 0041-008X. E-ISSN 1096-0333
Grant CEP: GA MŠk LH12040
Institucionální podpora: RVO:68081715
Klíčová slova: arsenic speciation * tissue * hydride generation
Kód oboru RIV: CB - Analytická chemie, separace
Impakt faktor: 3.630, rok: 2013

The insulin producing pancreatic β-cells are among the targets for As exposure and the inhibition of glucose stimulated insulin secretion by low concentrations of the methylated metabolites of iAs may be the key mechanism of iAs-induced diabetes.
Trvalý link: http://hdl.handle.net/11104/0217888