Počet záznamů: 1  

Stochastic simulation for the inference of transcriptional control network of yeast cyclins genes

  1. 1.
    0387082 - MBÚ 2013 RIV GB eng J - Článek v odborném periodiku
    Vohradský, Jiří
    Stochastic simulation for the inference of transcriptional control network of yeast cyclins genes.
    Nucleic Acids Research. Roč. 40, č. 15 (2012), s. 7096-7103. ISSN 0305-1048. E-ISSN 1362-4962
    Grant CEP: GA ČR GAP302/11/0229
    Institucionální podpora: RVO:61388971
    Klíčová slova: Cell cycle * gene expression * protein complexes
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 8.278, rok: 2012

    Cell cycle is controlled by the activity of protein family of cyclins and cyclin-dependent kinases that are periodically expressed during cell cycle and that are conserved among different species. Genome-wide location analysis found that cyclins are controlled by a small number of transcription factors that form closed network of genes controlling each other. To investigate gene expression dynamics of this network, we developed a general procedure for stochastic simulation of gene expression process. Using the binding data, we simulated gene expression of all genes of the network for all possible combinations of regulatory interactions and by statistical comparison with experimentally measured time series excluded those interactions that formed gene expression temporal profiles significantly different from the measured ones. These experiments led to a new definition of the cyclins regulatory network coherent with the binding experiments which are kinetically plausible. Level of influence of individual regulators in control of the regulated genes is defined. Simulation results indicate particular mechanism of regulatory activity of protein complexes involved in the control of cyclins
    Trvalý link: http://hdl.handle.net/11104/0220227

     
     
Počet záznamů: 1  

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