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Voltammetric Behavior of Methotrexate Using Mercury Meniscus Modified Silver Solid Amalgam Electrode

  1. 1.
    0384538 - ÚFCH JH 2013 RIV DE eng J - Článek v odborném periodiku
    Šelešovská, R. - Bandžuchová, L. - Navrátil, Tomáš
    Voltammetric Behavior of Methotrexate Using Mercury Meniscus Modified Silver Solid Amalgam Electrode.
    Electroanalysis. Roč. 23, č. 1 (2011), s. 177-178. ISSN 1040-0397. E-ISSN 1521-4109
    Grant CEP: GA AV ČR IAA400400806
    Výzkumný záměr: CEZ:AV0Z40400503
    Klíčová slova: methotrexate * voltammetry * determination
    Kód oboru RIV: CG - Elektrochemie
    Impakt faktor: 2.872, rok: 2011

    Voltammetric behavior of methotrexate (MTX), an important chemotherapeutic drug, has been investigated using electrochemical methods: cyclic voltammetry, direct current voltammetry and differential pulse voltammetry on a mercury meniscus modified silver solid amalgam electrode (m-AgSAE). The obtained results have been compared with those obtained using a hanging mercury drop electrode (HMDE). The optimal conditions for its determination have been found in a Britton-Robinson buffer of pH 5 with the limit of detection equal to 1.8 nM. RSD at this concentration level amounted to less than 4%. The proposed procedure of determination was verified on a real drug containing MTX.
    Trvalý link: http://hdl.handle.net/11104/0214155

     
     
Počet záznamů: 1  

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