0384133 - BC 2013 RIV GB eng J - Článek v odborném periodiku
Krejčí, Alena
Metabolic sensors and their interplay with cell signalling and transcription.
Biochemical Society Transactions. Roč. 40, č. 2 (2012), s. 311-323. ISSN 0300-5127. E-ISSN 1470-8752
Grant CEP: GA ČR(CZ) GAP305/11/0126
Grant ostatní: EMBO Installation Grant(CZ) 121/2010
Institucionální podpora: RVO:60077344
Klíčová slova: energy status * metabolic sensor * signalling
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.587, rok: 2012 ; AIS: 1.271, rok: 2012
Web výsledku:
http://www.biochemsoctrans.org/bst/040/0311/0400311.pdf

DOI: https://doi.org/10.1042/BST20110767

There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription.Central metabolic pathways are under the control of signalling pathways and, vice versa, cellular metabolic profile influences cell signalling through the incorporation of various metabolic sensors into the signalling networks. Thus information about nutrients availability directly and crucially influences crucial cell decisions. In the present review, I summarize our current knowledge of various metabolic sensors and give some examples of the integration of metabolically derived inputs into the signalling system and the regulation of transcription. I also discuss the Warburg effect where the cross-talk between metabolism and signalling is used to orchestrate rapid cell growth and division. It is becoming clear that future research will concentrate on the collection of small-molecule metabolites, whose concentration fluctuates in response to cellular energy levels, searching for their sensors that connect them to the signalling and transcriptional networks.
Trvalý link: http://hdl.handle.net/11104/0213868