0383620 - BFÚ 2013 RIV DE eng J - Článek v odborném periodiku
Betanzos-Lara, S. - Nováková, Olga - Deeth, R.J. - Pizarro, A.M. - Clarkson, G.J. - Lišková, Barbora - Brabec, Viktor - Sadler, P.J. - Habtemariam, A.
Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity.
Journal of Biological Inorganic Chemistry. Roč. 17, č. 7 (2012), s. 1033-1051. ISSN 0949-8257. E-ISSN 1432-1327
Grant CEP: GA ČR(CZ) GAP301/10/0598; GA ČR(CZ) GD301/09/H004
Výzkumný záměr: CEZ:AV0Z50040702
Klíčová slova: ruthenium(II) arene complexes * cytotoxicity * DNA binding
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.353, rok: 2012 ; AIS: 0.928, rok: 2012
DOI: https://doi.org/10.1007/s00775-012-0917-9

We have studied and contrasted the chemical reactivity of a series of organometallic RuII complexes of the type [(η6-arene)Ru(N,N’)X][PF6] containing an N,N‘ chelating ligand, as well as various arenes, and different halildes (X). Calf thymus DNA interactions for [(η6-p-cym)Ru(bpm)Cl][PF6] and [(η6-p-cym)Ru(phen)Cl][PF6] (cym=para cymene, bpm=2,2‘-bipyrimidine, phen=1,10-phenanthroline) consist of weak coordinative, intercalative and monofunctional coordination. Binding to biomolecules such as glutatione may play a role in deactivating the bpm complexes.
Trvalý link: http://hdl.handle.net/11104/0213502