Počet záznamů: 1  

Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening

  1. 1.
    0383277 - ÚOCHB 2013 RIV GB eng J - Článek v odborném periodiku
    Procházková, Eliška - Jansa, Petr - Březinová, Anna - Čechová, Lucie - Mertlíková-Kaiserová, Helena - Holý, Antonín - Dračínský, Martin
    Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening.
    Bioorganic and Medicinal Chemistry Letters. Roč. 22, č. 20 (2012), s. 6405-6409. ISSN 0960-894X. E-ISSN 1464-3405
    Institucionální podpora: RVO:61388963
    Klíčová slova: 5-aminopyrimidines * dimethyl sulphoxide * oxidation * self-condensation * pyrimidopteridines
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.338, rok: 2012

    The oxidation reactions of 5-aminopyrimidine derivatives in dimethyl sulphoxide (DMSO) were studied. The DMSO solutions of the studied compounds became deeply coloured within a few hours or days. The oxidation products can undergo further condensation reactions with the starting pyrimidines to yield bipyrimidines and/or pyrimidopteridines. The reaction mechanism of the oxidation-condensation reaction was also supported by reactions of the 5-aminopyrimidines with alloxan (2,4,5,6-tetraoxopyrimidine). DMSO is often used as the solvent in in vitro tests of biological activities, but it is also an oxidising agent and may react with solute molecules and significantly affect the quality of the generated biochemical data.
    Trvalý link: http://hdl.handle.net/11104/0213267

     
     
Počet záznamů: 1  

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