0382617 - ÚVGZ 2014 RIV CH eng C - Konferenční příspěvek (zahraniční konf.)
Kos, J. - Zadražilová, I. - Pesko, M. - Pavlica, J. - Gonec, T. - Bobál, P. - Oravec, Michal - Čížek, A. - Králová, K. - Jampílek, J.
Preparation and Biological Properties of Ring-Substituted 3-Hydroxynaphthalene-2-carboxanilides.
Proceedings of the 16th International Electronic Conference on Synthetic Organic Chemistry. Basilej: MDPI, 2013 - (Seijas, J.; Pilar Vázquez Tato, M.; Shu-Kun, L.), s. 1-16. ISBN 3-906980-26-X.
[International Electronic Conference on Synthetic Organic Chemistry /16./. Basilej (CH), 01.11.2012-30.11.2012]
Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0073
Institucionální podpora: RVO:67179843
Klíčová slova: Naphthalene-2-carboxanilides * PET inhibition * Spinach chloroplasts * Staphylococcus aureus * Structure-activity relationships
Kód oboru RIV: EH - Ekologie - společenstva
Web výsledku:
http://www.sciforum.net/presentation/1009

In this study a series of twenty-five ring-substituted 3-hydroxy-N-phenylnaphthalene-2-carboxanilides were prepared. The procedures for synthesis of the compounds are presented. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four Staphylococcus strains. Several compounds showed noteworthy biological activity especially against methicillin-resistant Staphylococcus aureus strains. For all the compounds structure-activity relationships (SAR) are discussed.
Trvalý link: http://hdl.handle.net/11104/0194525