Počet záznamů: 1  

Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

  1. 1. 0382291 - UOCHB-X 2013 RIV GB eng J - Článek v odborném periodiku
    Tichý, Michal - Pohl, Radek - Xu, H. Y. - Chen, Y. L. - Yokokawa, F. - Shi, P. Y. - Hocek, Michal
    Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides.
    Bioorganic & Medicinal Chemistry. Roč. 20, č. 20 (2012), s. 6123-6133. ISSN 0968-0896
    Grant CEP: GA ČR GAP207/11/0344
    Institucionální podpora: RVO:61388963
    Klíčová slova: nucleosides * deazapurines * antivirals
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.903, rok: 2012

    A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Some of these compounds displayed antiviral activity against Dengue virus.
    Trvalý link: http://hdl.handle.net/11104/0212553