Počet záznamů: 1  

PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA

  1. 1.
    0380748 - ÚEB 2013 RIV PL eng J - Článek v odborném periodiku
    ZIA-UL-HAQ, M. - ALI KHAN, B. - Landa, Přemysl - Kutil, Zsófia - AHMED, S. - QAYUM, M. - Ahmad, S.
    PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA.
    Acta Poloniae Pharmaceutica: drug research. Roč. 69, č. 4 (2012), s. 707-711. ISSN 0001-6837. E-ISSN 2353-5288
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: platelet aggregation * Garden pea * Desi chickpea
    Kód oboru RIV: EF - Botanika
    Impakt faktor: 0.665, rok: 2012
    http://home.ueb.cas.cz/publikace/2012_Haq_ACTA_POLONIAE_PHARMACEUTICA_707.pdf

    Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of Garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 = 35 μg/mL) and platelet activating factor (PAF)-induced platelet aggregation (IC50 = 38 μg/mL) in a dose dependent fashion. Methanolic extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 μg/mL) in dose dependent fashion while was found not active against PAF-induced platelet aggregation. Methanolic extract of Kabuli chickpea was found not active against both arachidonic acid (AA)-induced platelet aggregation and PAF-induced platelet aggregation. The best potential to inhibit in vitro COX-2 activity showed garden pea (Pisum sativum; the synthesis of PGE2 reduced by 92% in comparison with untreated control wells) followed by Desi chickpea (Cicer arietinum var; 87% inhibition) and Kabuli chickpea extracts (Cicer arietinum var; 65% inhibition). All extracts were tested at concentration 20 μg/mL. in COX-2 assay.The results indicate that if the same were happening in vivo, Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials.
    Trvalý link: http://hdl.handle.net/11104/0211379

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.