0380391 - BTÚ 2013 RIV DK eng A - Abstrakt
Elzeinová, Fatima - Pěknicová, Jana - Děd, Lukáš - Dorosh, Andriy - Kubátová, Alena - Margaryan, Hasmik - Makovický, P. - Rajmon, R.
Adverse effect of tetracycline and doxycycline on reproductive tract development of CD1 mice.
American Journal of Reproductive Immunology. Roč. 67, Issue Supplement s1 (2012), s. 47-48. ISSN 1046-7408. E-ISSN 1600-0897.
[13th International Symposium for Immunology of reproduction "From the roots to the tops of Reproductive Immunology". 22.06.2012-24.06.2012, Varna]
Grant CEP: GA ČR(CZ) GA523/09/1793; GA ČR(CZ) GAP503/12/1834
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: tetracycline * doxycycline * CD1 mice * reproduction
Kód oboru RIV: DN - Vliv životního prostředí na zdraví

Introduction: Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of male mice with the therapeutic dose used in humans. Methods: The outbred mouse strain CD1 with higher heterozygosity was exposed to three different doses for 14 days at puberty. Half of the therapeutic dose used in humans, the therapeutic dose, and double the therapeutic dose were used for the treatment. Adult males at the age of 70 days were used for the measurements. Results: We observed significant changes in most of the relevant reproductive parameters measured. There was a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and a lower number of acrosome-intact sperm was detected. Conclusion: The treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatozoa in adult males.
Trvalý link: http://hdl.handle.net/11104/0217283