Počet záznamů: 1  

Electronic and Vibrational Optical Activity of Several Peptides Related to Neurohypophyseal Hormones: Disulfide Group Conformation

  1. 1.
    0380158 - ÚOCHB 2013 RIV US eng J - Článek v odborném periodiku
    Pazderková, Markéta - Bednárová, Lucie - Dlouhá, Helena - Flegel, Martin - Lebl, M. - Hlaváček, Jan - Setnička, V. - Urbanová, M. - Hynie, S. - Klenerová, V. - Baumruk, V. - Maloň, Petr
    Electronic and Vibrational Optical Activity of Several Peptides Related to Neurohypophyseal Hormones: Disulfide Group Conformation.
    Biopolymers. Roč. 97, č. 11 (2012), s. 923-932. ISSN 0006-3525. E-ISSN 1097-0282
    Grant CEP: GA ČR GAP205/10/1276
    Grant ostatní: GA UK(CZ) 578212
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: neurohypophyseal hormones * disulfide bridge * Raman optical activity * vibrational circular dichroism
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 2.879, rok: 2012

    Electronic and vibrational optical activity of the set of neurohypophyseal hormones and their analogs was investigated to clarify the S-S bond solution conformation. The selected compounds include oxytocin (I), lysine vasopressin (II), arginine vasopressin (III), and their analogs (IV-IX), differing widely in their pharmacological properties. We have extended the already known electronic circular dichroism data by new information provided by vibrational circular dichroism (VCD) and Raman optical activity (ROA). The use of VCD brought additional details on three-dimensional structure of the chain reversal in the ring moiety and on its left handedness. Furthermore, Raman scattering and ROA allowed us to deduce the sense of the disulfide bond torsion.
    Trvalý link: http://hdl.handle.net/11104/0210943

     
     
Počet záznamů: 1  

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