Počet záznamů: 1  

Neuroactive steroids with perfluorobenzoyl group

  1. 1.
    0380142 - ÚOCHB 2013 RIV US eng J - Článek v odborném periodiku
    Černý, Ivan - Buděšínský, Miloš - Pouzar, Vladimír - Vyklický, Vojtěch - Krausová, Barbora - Vyklický ml., Ladislav
    Neuroactive steroids with perfluorobenzoyl group.
    Steroids. Roč. 77, č. 12 (2012), s. 1233-1241. ISSN 0039-128X. E-ISSN 1878-5867
    Grant CEP: GA ČR(CZ) GAP303/12/1464; GA TA ČR TE01020028; GA ČR(CZ) GBP304/12/G069
    Institucionální podpora: RVO:61388963 ; RVO:67985823
    Klíčová slova: neuroactive steroids * synthesis * perfluorobenzoates * NMDA receptor
    Kód oboru RIV: CC - Organická chemie; ED - Fyziologie (FGU-C)
    Impakt faktor: 2.803, rok: 2012

    Perfluorobenzoates and perfluorobenzamides in position 17 of 5beta-androstan-3alpha-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. Their glutamates or sulfates were tested for inhibitory activity at NMDA receptors. 17alpha-epimers were more potent than their 17b-substituted analogs. The series was expanded with perfluorobenzoate of 11alpha-hydroxy pregnanolone. From nine tested compounds, four of them exhibit very good inhibition activity and can serve as promising leads for photolabeling experiments.
    Trvalý link: http://hdl.handle.net/11104/0215858

     
     
Počet záznamů: 1  

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