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Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs

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    0377249 - BC 2013 RIV US eng J - Článek v odborném periodiku
    Kváč, Martin - Kestřánová, M. - Květoňová, Dana - Kotková, M. - Ortega, Y. - McEvoy, J. - Sak, Bohumil
    Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs.
    Experimental Parasitology. Roč. 131, č. 1 (2012), s. 107-110. ISSN 0014-4894. E-ISSN 1090-2449
    Grant CEP: GA MŠk(CZ) LH11061
    Grant ostatní: GA ČR(CZ) GA206/08/0640
    Program: GA
    Institucionální podpora: RVO:60077344
    Klíčová slova: Pigs * Cryptosporidium tyzzeri * Cryptosporidium muris * Experimental infection * PCR * Histology
    Kód oboru RIV: GJ - Choroby a škůdci zvířat, veterinární medicína
    Impakt faktor: 2.154, rok: 2012
    http://www.sciencedirect.com/science/article/pii/S0014489412001105

    Three and 8 week old pigs were inoculated with Cryptosporidium muris HZ206 (Mus musculus musculus isolate), Cryptosporidium tyzerri CR2090 (M. m. musculus isolate) or C. tyzzeri CR4293 (isolate from a hybrid between Mus musculus domesticus and M. m. musculus) at a dose of 1 _ 107 oocysts per animal. Inoculated pigs showed no detectable infection and no clinical symptoms of cryptosporidiosis during 30 days post infection (DPI), and no macroscopic changes were detected in the digestive tract following necropsy. Developmental stages were not detected in gastrointestinal tract tissue by histology or PCR throughout the duration of the experiment. The infectivity of isolates was verified on SCID mice, in which oocysts shedding started from 4 to 8 DPI. Based on our findings, it can be concluded that pigs are not susceptible to C. muris or C. tyzzeri infection.
    Trvalý link: http://hdl.handle.net/11104/0209457

     
     
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