Novel "soft" biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

0376067 - ÚMCH 2013 RIV GB eng J - Článek v odborném periodiku
Jäger, Alessandro - Gromadzki, Daniel - Jäger, Eliezer - Giacomelli, F. C. - Kozlowska, A. - Kobera, Libor - Brus, Jiří - Říhová, Blanka - El Fray, M. - Ulbrich, Karel - Štěpánek, Petr
Novel "soft" biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system.
Soft Matter. Roč. 8, č. 16 (2012), s. 4343-4354. ISSN 1744-683X. E-ISSN 1744-6848
Grant CEP: GA AV ČR IAAX00500803; GA ČR GAP208/10/1600
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Klíčová slova: biodegradable nanoparticles * light scattering from polymer nanoparticles * drug release
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 3.909, rok: 2012

Herein, the synthesis and characterization of a new aliphatic biodegradable copolyester named PBS/PBDL (poly(butylene succinate-co-butylene dilinoleate)) is reported. Surfactant-free, narrowly distributed, nanosized spherical particles (RH < 60 nm) have been produced from the biodegradable material by applying a single-step nanoprecipitation protocol. Their structure was characterized in detail by employing a variety of scattering techniques and transmission electron microscopy (TEM). Combined SLS and DLS measurements suggested that the nanoparticles comprise a porous core conferring a non-compact characteristic. Their porosity enables water to be entrapped which is responsible for their pronounced stability and relatively fast degradation as followed by size exclusion chromatography (SEC).
Trvalý link: http://hdl.handle.net/11104/0208568