The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population

0375938 - ÚMG 2013 RIV US eng J - Článek v odborném periodiku
Svobodová, Eliška - Krulová, Magdalena - Zajícová, Alena - Pokorná, Kateřina - Procházková, Jana - Trošan, Peter - Holáň, Vladimír
The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population.
Stem Cells and Development. Roč. 21, č. 6 (2012), s. 901-910. ISSN 1547-3287. E-ISSN 1557-8534
Grant CEP: GA AV ČR KAN200520804; GA MŠMT 1M0506; GA ČR GAP304/11/0653; GA ČR GD310/08/H077; GA ČR(CZ) GAP301/11/1568
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: mesenchymal stem cells * immunomodulation * T-cell development
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.670, rok: 2012

Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions.
Trvalý link: http://hdl.handle.net/11104/0216423