Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles

0373396 - BFÚ 2012 RIV US eng J - Článek v odborném periodiku
Zerzánková, Lenka - Suchánková, T. - Vrána, Oldřich - Farrell, N.P. - Brabec, Viktor
Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
Biochemical Pharmacology. Roč. 79, č. 2 (2010), s. 112-121. ISSN 0006-2952. E-ISSN 1873-2968
Grant CEP: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Klíčová slova: antitumor * dinuclear platinum complex * DNA damage
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.889, rok: 2010

A detailed biochemical and molecular biophysics study of the molecular mechanism of action of a new dinuclear PtII complex [{PtCl(1,2-diaminocyclohexane)}2-my-Y]4+, resistant to decomposition by sulfur nucleophiles, was reported herein. The results show that this complex exhibits promising antitumor features as its DNA adducts can largely escape repair and inhibit very effectively transcription.
Trvalý link: http://hdl.handle.net/11104/0206505