Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry

0370154 - ÚOCHB 2012 RIV NL eng J - Článek v odborném periodiku
Jirásková-Vaníčková, Jana - Ettrich, Rüdiger - Vorlová, Barbora - Hoffman, Hillary Elizabeth - Lepšík, Martin - Jansa, Petr - Konvalinka, Jan
Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry.
Current Drug Targets. Roč. 12, č. 7 (2011), s. 1037-1055. ISSN 1389-4501. E-ISSN 1873-5592
Grant CEP: GA MŠMT 1M0508; GA ČR GA203/08/0114
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z60870520
Klíčová slova: amino acid analogs * L-erythro-3-hydroxyaspartate (L-EHA) * D-serine * neurodegenerative diseases * NMDA receptors * pyridoxal-5´-phosphate (PLP)
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 3.553, rok: 2011

Proteins of glutamatergic NMDA receptor signaling pathways have been studied as targets for intervention in a variety of neuropathological conditions, including neurodegenerations, epilepsy, neuropathic pain, drug addiction, and schizophrenia. High activity NMDA-blocking agents have been designed to treat some of these disorders; however, their effect is often compromised by undesirable side effects. Therefore, alternative ways of modulating NMDA receptor function need to be sought after.
Trvalý link: http://hdl.handle.net/11104/0204037