Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis

0366038 - ÚEB 2012 RIV US eng J - Článek v odborném periodiku
Marhavý, P. - Bielach, A. - Abas, L. - Abuzeineh, A. - Duclercq, J. - Tanaka, H. - Pařezová, Markéta - Petrášek, Jan - Friml, J. - Kleine-Vehn, J. - Benková, E.
Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.
Developmental Cell. Roč. 21, č. 4 (2011), s. 796-804. ISSN 1534-5807. E-ISSN 1878-1551
Grant CEP: GA AV ČR(CZ) IAA601630703; GA MŠMT(CZ) LC06034
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: auxin efflux * cytokinin * vacuoles * membrane trafficking
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 14.030, rok: 2011

Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes.
Trvalý link: http://hdl.handle.net/11104/0201138