Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor

0364584 - ÚEM 2012 RIV US eng J - Článek v odborném periodiku
Hovořáková, Mária - Procházka, Jan - Lesot, H. - Smrčková, Lucie - Churavá, Svatava - Boráň, T. - Kozmik, Zbyněk - Klein, O. - Peterková, Renata - Peterka, Miroslav
Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor.
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. 346B, č. 5 (2011), s. 347-358. ISSN 1552-5007. E-ISSN 1552-5015
Grant CEP: GA ČR GA304/07/0223; GA ČR GA304/09/1579
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50520514
Klíčová slova: morphogenesis * human embryos * deciduous dentition
Kód oboru RIV: EA - Morfologické obory a cytologie
Impakt faktor: 2.416, rok: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0364584_01.pdf

Using a combination of histology, 3D reconstructions and Shh whole mount in situ hybridization (WISH) analyses, several Sonic hedgehog (Shh) expression domains have been shown sequentially appearing in the lower WT mouse incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, two spatially distinct regions of Shh expression have been identified that appeared in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so-called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. These findings strongly suggest the necessity to re-interpret previous results based on either morphology alone or on the detection of signaling molecules alone, and offer a new insight into the interpretation of existing data from mutant mice.
Trvalý link: http://hdl.handle.net/11104/0200033