Functional inactivation of the rat hippocampus disrupts avoidance of a moving object

0364564 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Telenský, P. - Svoboda, Jan - Blahna, Karel - Bureš, Jan - Kubík, Štěpán - Stuchlík, Aleš
Functional inactivation of the rat hippocampus disrupts avoidance of a moving object.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 108, č. 13 (2011), s. 5414-5418. ISSN 0027-8424. E-ISSN 1091-6490
Grant CEP: GA ČR(CZ) GA309/09/0286; GA ČR(CZ) GCP303/10/J032; GA ČR GPP303/10/P191; GA AV ČR(CZ) KJB500110904; GA MŠMT(CZ) 1M0517; GA MŠMT(CZ) LC554; GA ČR(CZ) GD206/05/H012
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: cognitive map * declarative memory * episodic memory * dynamic environments
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 9.681, rok: 2011

The work shows that avoidance of a visible moving object (a small robot) relies on the hippocampus, an archicortical brain area considered to be crucial for memory and spatial navigation. Navigation with respect to a stable robot did not require hippocampus. Study was done in an original enemy avoidance task, hippocampus was functionally inactivated by stereotaxic injection of tetrodotoxin. The study represents crucial finding extending the cognitive map theory of the hippocampus function
Trvalý link: http://hdl.handle.net/11104/0200019