Počet záznamů: 1
Azido analogs of neuroactive steroids
- 1.0361126 - ÚOCHB 2012 RIV US eng J - Článek v odborném periodiku
Vidrna, Lukáš - Černý, Ivan - Pouzar, Vladimír - Borovská, Jiřina - Vyklický, Vojtěch - Vyklický ml., Ladislav - Chodounská, Hana
Azido analogs of neuroactive steroids.
Steroids. Roč. 76, 10/11 (2011), s. 1043-1050. ISSN 0039-128X. E-ISSN 1878-5867
Grant CEP: GA MŠMT(CZ) LC06077; GA MŠMT(CZ) LC554; GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/07/0271
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50110509
Klíčová slova: neuroactive steroids * synthesis * azides * NMDA receptor
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.829, rok: 2011
Analogs of neurosteroid pregnanolone, modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely or only partially by azide were synthesized and converted into corresponding sulfates. Tests for inhibition of glutamate induced response on NMDA receptors revealed retaining of the activity in some extent, three of sulfates tested were more active than parent compound.
Trvalý link: http://hdl.handle.net/11104/0198523
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Počet záznamů: 1