Polysaccharides in Medicinal and Pharmaceutical Applications

0361112 - ÚOCHB 2012 RIV GB eng M - Část monografie knihy
Šebestík, Jaroslav - Reiniš, Milan - Ježek, Jan
Carbohydrate-Containing Dendrimers in Biomedical Applications.
Polysaccharides in Medicinal and Pharmaceutical Applications. Shawbury: iSmithers, 2011 - (Popa, V.), s. 353-384. ISBN 978-1-84735-437-2
Grant CEP: GA ČR GA203/07/1517; GA AV ČR IAA400550702
Grant ostatní: AV ČR(CZ) M200550902
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Klíčová slova: dendrimers * drug delivery * gene delivery * glycobiology * glycoclusters
Kód oboru RIV: CC - Organická chemie
http://www.ismithers.net

Glycodendrimers are (regularly) branched structures containing carbohydrates. Many of these compounds with various composition and structure are mentioned; as well as, their practical applications spanning from drug and gene deliveries, synthetic vaccines, prevention of pathological processes caused by bacteria and viruses, etc. A dendrimeric state, physicochemical properties of dendrimers, and general consequences are reviewed with emphasis to a cluster effect and multivalency. Two main approaches of glycodendrimer syntheses - convergent and divergent - are described. Since glycopeptide dendrimers suppress lectin-carbohydrate interactions, glycodendrimeric libraries provide potent inhibitors of bacterial adhesion and biofilm formation.
Trvalý link: http://hdl.handle.net/11104/0198516