Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights

0360784 - ÚMCH 2012 RIV DE eng J - Článek v odborném periodiku
Rodriguez-Emmenegger, Cesar Adolfo - Schmidt, B. V. K. J. - Sedláková, Zdeňka - Šubr, Vladimír - Bologna Alles, A. - Brynda, Eduard - Barner-Kowollik, C.
Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights.
Macromolecular Rapid Communications. Roč. 32, č. 13 (2011), s. 958-965. ISSN 1022-1336. E-ISSN 1521-3927
Grant CEP: GA AV ČR KAN200670701; GA AV ČR IAAX00500803
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: biofouling * carboxybetaine methacrylamide * low temperature polymerization
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 4.596, rok: 2011

Poly(carboxybetaine)s (poly(CB)s) are unique, emerging as the only ultra-low fouling materials allowing the preparation of biosensors, fouling resistant nanoparticles, and non-adhesive surfaces for bacteria. Poly(CB)s have been prepared via atom transfer radical polymerization, however no control was achieved. Herein, the first successful living/controlled reversible addition fragmentation transfer polymerization of (3-methacryloylamino-propyl)-(2-carboxy-ethyl)-dimethyl-ammonium in acetate buffer (pH 5.2) at 70 and 37 °C is reported. The polymerization afforded very high molecular weight polymers (250 000 g • mol−1 in less than 6 h) with low PDI (<1.3) at 70 °C. The polymerization was additionally carried out at 37 °C achieving yet lower PDIs (1.06 ≤ PDI ≤ 1.15) even at 90% conversion, demonstrating the suitability of the polymerization conditions for bioconjugate grafting. Block copolymerization from biologically relevant poly[HPMA] macroCTAs was additionally performed.
Trvalý link: http://hdl.handle.net/11104/0198252