Adenosine and ATP Receptors in the Brain

0360461 - ÚEM 2012 RIV NL eng J - Článek v odborném periodiku
Burnstock, G. - Fredholm, B. B. - Verkhratsky, Alexei
Adenosine and ATP Receptors in the Brain.
Current Topics in Medicinal Chemistry. Roč. 11, č. 8 (2011), s. 973-1011. ISSN 1568-0266. E-ISSN 1873-4294
Grant CEP: GA ČR GA309/08/1381; GA ČR GA305/08/1384
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: Ischaemia * CNS * glia
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.174, rok: 2011

Here we review a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells; the role of P1 and P2 receptors in neurone-glia interactions, in presynaptic neuromodulation (P1 receptors), in fast synaptic transmission and synaptic plasticity (P2X receptors) and in presynaptic activities (P2Y receptors). Purinergic signalling is involved in neuropathology , such as Parkinson's disease and epilepsy, trauma, ischaemia.
Trvalý link: http://hdl.handle.net/11104/0006483