Guanidinium Cations Pair with Positively Charged Arginine Side Chains in Water

0360095 - ÚOCHB 2012 RIV US eng J - Článek v odborném periodiku
Kubíčková, A. - Křížek, T. - Coufal, P. - Wernersson, Erik - Heyda, Jan - Jungwirth, Pavel
Guanidinium Cations Pair with Positively Charged Arginine Side Chains in Water.
Journal of Physical Chemistry Letters. Roč. 2, č. 12 (2011), s. 1387-1389. ISSN 1948-7185
Grant CEP: GA ČR GA203/08/0114; GA MŠMT LC512
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: guanidinium * cations * arginine * electrophoresis * water
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 6.213, rok: 2011

Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.
Trvalý link: http://hdl.handle.net/11104/0197730