Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes

0359971 - ÚFCH JH 2012 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Vyskočil, V. - Navrátil, Tomáš - Barek, J.
Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes.
Sborník přednášek. XXXI. Moderní elektrochemické metody. Ústí nad Labem: BEST servis, 2011 - (Navrátil, T.; Barek, J.), s. 190-194. ISBN 978-80-254-9634-3.
[Moderní elektrochemické metody /31./. Jetřichovice (CZ), 23.05.2011-27.05.2011]
Grant CEP: GA AV ČR IAA400400806; GA ČR GAP206/11/1638
Výzkumný záměr: CEZ:AV0Z40400503
Klíčová slova: creatine * screen-printed carbon electrodes * flutamide
Kód oboru RIV: CG - Elektrochemie

Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide, is the active component of a synthetic nonsteroidal antiandrogen drug, which is commonly used in the treatment of advanced prostate cancer. In this contribution, optimum conditions have been found vor voltammetric determination of flutamide by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). Under optimum conditions (Britton-Robinson buffer pH 7.0 - methanol (9:1)), linear calibration curves were measure with limits of quantification 6x10(-7) molL(-1) and 8x10(-7) molL(-1) for DCV at SPCEs, respectively. The newly developed methods were successfully applied to the determination of the drug in pharmaceutical formulation Apo-Flutamide (Eulexin tablets).
Trvalý link: http://hdl.handle.net/11104/0197638