Production of proteolytic enzymes in mast cells, fibroblasts, vascular smooth muscle and endothelial cells cultivated under normoxic or hypoxic conditions

0355375 - FGÚ 2011 RIV CZ eng J - Článek v odborném periodiku
Maxová, H. - Bačáková, Lucie - Lisá, Věra - Novotná, J. - Tomášová, H. - Vízek, M. - Herget, J.
Production of proteolytic enzymes in mast cells, fibroblasts, vascular smooth muscle and endothelial cells cultivated under normoxic or hypoxic conditions.
Physiological Research. Roč. 59, č. 5 (2010), s. 711-719. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA305/08/0108; GA MŠMT(CZ) 1M0510
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: hypoxia * metalloproteinases * tryptase * chymase * immunofluorescence
Kód oboru RIV: EI - Biotechnologie a bionika
Impakt faktor: 1.646, rok: 2010

We tested in vitro production of MMPs and serine proteases in four cell types cultivated for 48 h under normoxic or hypoxic conditions. Among all cell types, mast cells are the most abundant source of proteolytic enzymes under normoxic and hypoxic conditions. Morover, in these cells hypoxia increases the production of both specific serine proteases trypase and chymase, which can act as MMPs activators
Trvalý link: http://hdl.handle.net/11104/0194159