Characterization of Pseudacyclins A-E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii

0354251 - MBÚ 2011 RIV US eng J - Článek v odborném periodiku
Pavlásková, Kateřina - Nedvěd, Jan - Kuzma, Marek - Žabka, Martin - Šulc, Miroslav - Sklenář, Jan - Novák, Petr - Benada, Oldřich - Kofroňová, Olga - Hajduch, M. - Derrick, P.J. - Lemr, Karel - Jegorov, A. - Havlíček, Vladimír
Characterization of Pseudacyclins A-E, a Suite of Cyclic Peptides Produced by Pseudallescheria boydii.
Journal of Natural Products. Roč. 73, č. 6 (2010), s. 1027-1032. ISSN 0163-3864. E-ISSN 1520-6025
Grant CEP: GA MŠMT LC07017
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: EMERGING HUMAN PATHOGEN * SCEDOSPORIUM-APIOSPERMUM * ASPERGILLUS-FUMIGATUS
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 2.872, rok: 2010

Two Pseudallescheria boydii isolates have been identified as being producers of cyclic peptides. Five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. The most abundant representative of the pseudacyclins was quantified also on fungal spores. The presence of these peptides on inhaled fungal spores creates the possibility for exploitation of pseudacyclins as early indicators of fungal infections caused by Pesudallescheria species
Trvalý link: http://hdl.handle.net/11104/0193298