HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes

0353449 - ÚMG 2011 RIV US eng J - Článek v odborném periodiku
Hodný, Zdeněk - Mistrik, M. - Bártek, Jiří
HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes.
Cell Cycle. Roč. 9, č. 7 (2010), s. 1227-1228. ISSN 1538-4101. E-ISSN 1551-4005
Grant CEP: GA ČR GA301/08/0353
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: DNA damage response * HERC2 * ubiquitylation
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.999, rok: 2010

Targeting of proteins to DNA double strand breaks is highly organized hierarchical process, which depends on posttranslational modifications such as phosphorylation, ubiquitylation and sumoylation. This short review summarizes newly discovered role of protein HERC2, which is targeted to DNA double strand breaks by ATM kinase mediated phosphorylation, where it serves as adaptor protein for ubiquitylation enzymes E3 ligases RNF8 and RNF168 and specifity factor for E2 ligase UBC13. Possible relationship of HERC2 genetic alterations to some human diseases is also discussed.
Trvalý link: http://hdl.handle.net/11104/0192697