Determination of acid-base dissociation constants of very weak zwitterionic heterocyclic bases by capillary zone electrophoresis

0351530 - ÚOCHB 2011 RIV NL eng J - Článek v odborném periodiku
Ehala, Sille - Grishina, Anastasia - Sheshenev, Andrey - Lyapkalo, Ilya - Kašička, Václav
Determination of acid-base dissociation constants of very weak zwitterionic heterocyclic bases by capillary zone electrophoresis.
Journal of Chromatography A. Roč. 1217, - (2010), s. 8048-8053. ISSN 0021-9673. E-ISSN 1873-3778
Grant CEP: GA ČR(CZ) GA203/08/1428; GA ČR(CZ) GA203/09/0675
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: acidity constant * capillary zone electrophoresis * zwitterionic heterocyclic bases
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 4.194, rok: 2010

Thermodynamic acid-base dissociation (ionization) constants (pKa) of seven very weak zwitterionic heterocyclic bases, originally designed as chiral Lewis base catalysts for enantioselective reactions, were determined by capillary zone electrophoresis (CZE). The pKa values of these compounds were found to be particularly low, in the range 0.04-0.32. Moreover, from the pH dependence of effective mobility of the bases, some other relevant characteristics, such as actual and absolute ionic mobilities and hydrodynamic radii of the acidic cationic forms of the bases were determined.
Trvalý link: http://hdl.handle.net/11104/0191264