Rapid effector function of circulating CD4+T cells specific for immunodominant regions of the conserved serine/threonine kinase found in Streptococcus pneumoniae (StkP) in healthy adults

0351523 - MBÚ 2011 RIV NL eng J - Článek v odborném periodiku
Aslam, A. - Mason, A. - Zemenides, S. - Chan, H. - Nováková, Linda - Branny, Pavel - Finn, A. - Chapel, H. - Ogg, G. S.
Rapid effector function of circulating CD4+T cells specific for immunodominant regions of the conserved serine/threonine kinase found in Streptococcus pneumoniae (StkP) in healthy adults.
FEMS Immunology and Medical Microbiology. Roč. 60, č. 2 (2010), s. 113-122. ISSN 0928-8244
Grant CEP: GA ČR GP204/07/P082; GA ČR GA204/08/0783
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: epitopes * pneumococcus * ELISpot
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 2.494, rok: 2010

This is the first study that has identified T-cell responses to peptides derived from a protein (StkP) from S. pneumoniae and has shown that in healthy adults, specific T cells have rapid IFN-g production compatible with effector cell differentiation. The use of such T-cell epitopes will aid in the future monitoring of T-cell responses to both S. pneumoniae infection and vaccination in humans
Trvalý link: http://hdl.handle.net/11104/0191259