Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

0349610 - ÚEM 2011 RIV GB eng J - Článek v odborném periodiku
Campa, D. - Pardini, Barbara - Naccarati, Alessio - Vodičková, Ludmila - Novotný, J. - Steinke, V. - Rahner, N. - Holinski-Feder, E. - Morak, M. - Schackert, H. K. - Görgens, H. - Kötting, J. - Betz, B. - Kloor, M. - Engel, C. - Büttner, R. - Propping, P. - Försti, A. - Hemminki, K. - Barale, R. - Vodička, Pavel - Canzian, F.
Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.
BMC Gastroenterology. Roč. 10, - (2010), s. 112-117. E-ISSN 1471-230X
Grant CEP: GA ČR GA310/05/2626
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: colorectal cancer * insulin * GHSR
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.468, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349610_01.pdf

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. Pairwise tagging was used to select the 11 polymorphisms and the selected polymorphisms were genotyped in cases and controls from the Czech Republic and further verified on the German population. T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).
Trvalý link: http://hdl.handle.net/11104/0006106