Počet záznamů: 1
Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits
- 1.0348192 - FGÚ 2011 RIV US eng J - Článek v odborném periodiku
Bouřová, Lenka - Vošahlíková, Miroslava - Kagan, D. - Dlouhá, Kateřina - Novotný, J. - Svoboda, Petr
Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits.
Medical Science Monitor. Roč. 16, č. 8 (2010), BR260-BR270. ISSN 1234-1010
Grant CEP: GA AV ČR(CZ) IAA500110606; GA MŠMT(CZ) LC554
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: morphine * G-protein * opioid receptors
Kód oboru RIV: CE - Biochemie
Impakt faktor: 1.699, rok: 2010
Our data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of opioid receptors-response preferentially oriented to micro- and delta-opioid receptors. Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of opioid receptors-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins
Trvalý link: http://hdl.handle.net/11104/0188782
Počet záznamů: 1