Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro

0346777 - BTÚ 2011 RIV US eng J - Článek v odborném periodiku
Čtrnáctá, Vlasta - Fritzler, J. M. - Šurínová, M. - Hrdý, I. - Zhu, G. - Stejskal, F.
Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro.
Experimental Parasitology. Roč. 126, č. 2 (2010), s. 113-116. ISSN 0014-4894. E-ISSN 1090-2449
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: S-adenosylhomocysteine hydrolase * D-eritadenine * (S)-DHPA
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.869, rok: 2010

D-eritadenine and (S)-DHPA are aliphatic adenosine analogues known to target S-adenosylhomocysteine hydrolase (SAHH) and potent antiviral compounds. In the present study, we demonstrate that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro. Our data confirm that SAHH could serve as a rational drug target in cryptosporidial infection and antiviral adenosine analogues are potential candidates for drug development against cryptosporidiosis
Trvalý link: http://hdl.handle.net/11104/0187708